Israel strikes Iran as explosions are reported in Iraq and Syria as Netanyahu defies Biden warnings and retaliates after Tehran launched unprecedented missile barrage on the Jewish state

Israel has conducted airstrikes on a target in Iran, US officials say. 

An official told ABC News that strikes hit a site in Iran, however it is unclear what target was hit or the extent of the damage. 

Footage shared on social media appeared to show anti-aircraft fire striking over the city of Isfahan in central Iran, which hosts one of Iran's nuclear facilities. 

It comes in response to Iran launching a barrage of hundreds of drones and rockets at Israel on Saturday, which was largely thwarted by Israel and its international allies. 

The Biden administration had stressed the need for de-escalation from Israel following Saturday's strikes.  

Further explosions have reportedly hit Iraq and Syria. 

Florida Senator Marco Rubio tweeted soon after reports of the strikes: 'Israel has the ability to conduct strikes against targets inside Iran without entering Iranian air space from aircraft over Syrian and Iraqi airspace.'